BMB:3110 Biochemistry 3 s.h.

One-semester survey of basic concepts in modern biochemistry and molecular biology; emphasis on application of biochemical concepts to human metabolism; appropriate for students who plan to pursue a career in health care or want an overview of biochemistry as a discipline. Requirements: one year each of college-level biology and chemistry. Recommendations: one semester of organic chemistry.

BMB:3120 Biochemistry and Molecular Biology I 3 s.h.

Physical and chemical foundations of biochemistry, structure of biological molecules, catalysis, transport, and oxidative reactions in biology; first of two-semester sequence that concludes with BMB:3130. Requirements: two semesters of general chemistry and one of organic chemistry. Recommendations: BIOL:1411, BIOL:1412, and an additional organic chemistry course.

BMB:3130 Biochemistry and Molecular Biology II 3 s.h.

Molecular principles of photosynthesis and biosignaling; metabolism of lipids, amino acids, and nucleic acids; DNA replication, transcription, and protein translation; team-taught, didactic lecture style; second of a two-semester comprehensive biochemistry sequence. Prerequisites: BMB:3120 with a minimum grade of C-.

BMB:3140 Experimental Biochemistry 2 s.h.

Use of modern instruments and techniques to fractionate, identify, and characterize constituents of biochemical systems. Prerequisites: BMB:3120 with a minimum grade of C-. Requirements: two semesters of general chemistry and one semester of organic chemistry.

BMB:3150 Development of Senior Research Project 2 s.h.

Preparation for biochemistry majors pursuing a senior research project in BMB:4999; communicating technical information through writing and speaking; presenting scientific journal articles and writing experimental protocols; developing detailed proposal for one-year senior research project. Prerequisites: BMB:3120 or BMB:3140 or BMB:3130. Requirements: biochemistry major, and junior or senior standing.

BMB:3310 Practical Data Science and Bioinformatics 3 s.h.

Understanding how to access large biological data sets and use them to answer biological questions is an important skill for researchers; immersive introduction to computational handling of data; how to access and analyze publicly available data; critically evaluate data quality and analysis in context of measuring gene expression; basic coding in R/RStudio, plotting and data display, fitting and regression, statistical inference, statistical models, downloading and data wrangling; basic introduction to machine learning (clustering); for students with no computational background. Prerequisites: BIOL:1411 with a minimum grade of C- and BIOL:1412 with a minimum grade of C-. Requirements: college algebra. Recommendations: BMB:3110, or BMB:3120 and BMB:3130, or other upper-level life sciences courses. Same as CBIO:3310, MMED:3310.

BMB:3800 Biochemistry Teaching Practicum arr.

Training for qualified junior or senior undergraduates majoring in biochemistry or a related field to contribute to undergraduate courses; interns may hold review sessions, offer regular office hours, draft questions for homework or exams, assist in proctoring exams, assist students in a laboratory setting, and help with course implementation; guidance from the faculty director and instructors in each course; interns are expected to work approximately three hours per week for each semester hour of credit earned. Requirements: completion of a course covering the same or equivalent material with a grade of B or higher, and must arrange for a short interview with the appropriate course director prior to registration.

BMB:3993 Undergraduate Biochemistry Research arr.

Preparation for BMB:4999; directed research with a biochemistry faculty member; experience in an active biochemistry research lab, learning and performing experiments relevant to current projects in that lab, including exposure to scientific literature; arranged in advance by student and biochemistry faculty member.

BMB:4240 Biophysics and Advanced Biochemistry 3 s.h.

Principles and experimental approaches used to study macromolecular structure, stability, and function; ligand binding and macromolecular interactions; enzyme kinetics and mechanisms; X-ray crystallography and NMR spectroscopy; single molecule and other biophysical approaches. Prerequisites: BMB:3120 and BMB:3130 with a minimum grade of C-. Requirements: one year of biochemistry. Recommendations: physical chemistry course and one semester of calculus.

BMB:4310 Computational Biochemistry 3 s.h.

Introduction to biomolecular modeling and computer simulation techniques; biomolecular structure and molecular driving forces; principles of structural optimization and conformational sampling; applications to biomolecular phenotypes; scripting and molecular visualization in PyMol, setting up and running molecular dynamics simulations using VMD and NAMD, performing refinement of X-ray diffraction data sets using Phenix, and executing Poisson-Boltzmann electrostatic calculations using APBS. Prerequisites: (MATH:1560 or MATH:1860) and CHEM:1120. Recommendations: BMB:3110 or BMB:3120. Same as BME:4310.

BMB:4999 Advanced Undergraduate Biochemistry Research arr.

Advanced directed research with a biochemistry faculty member; work on an individualized research project relevant to research goals of that lab; learning related scientific literature and presentation of research results; arranged in advance by student and biochemistry faculty member and taken after completion of core biochemistry curriculum. Prerequisites: BMB:3120 with a minimum grade of B- and BMB:3130 with a minimum grade of B- and BMB:3140 with a minimum grade of B- and BMB:3150 with a minimum grade of B-. Requirements: BMB:3993 or URES:3994 or HONR:3994 or prior research experience or lab practicum.

BMB:5215 Directed Readings for Graduate Students arr.

Directed readings with course content arranged with professor.

BMB:5240 Biophysics and Advanced Biochemistry 3 s.h.

Principles and experimental approaches used to study macromolecular structure, stability, and function; ligand binding and macromolecular interactions; enzyme kinetics and mechanisms; X-ray crystallography and NMR spectroscopy; single molecule and other biophysical approaches. Requirements: one year of biochemistry. Recommendations: physical chemistry course and one semester of calculus.

BMB:5244 Molecular Recognition 1 s.h.

Focus on determinants in protein small molecule binding, particularly involving pharmaceutically relevant enzymes and receptors; how modern structure-based drug discovery is greatly aided by ability to employ protein structures in discovery and design of certain classes of drugs; structural approaches for predicting and improving drug affinity and selectivity, which have made a lasting impact across a number of diseases; important contemporary topics include in-depth lectures on fragment based drug discovery (FBDD), use and pitfalls of in silico docking and other screening methods, and emergence of covalent drugs. Requirements: introductory course in biochemistry. Same as PHAR:5542.

BMB:5261 Research Techniques 1-6 s.h.

Laboratory rotation for first-year graduate students in biochemistry.

BMB:5282 Seminar 0-2 s.h.

How to evaluate reports of scientific investigations critically; techniques for presenting scientific information.

BMB:5875 Perspectives in Biotechnology 1 s.h.

Topics related to careers in biotechnology with an emphasis on preparing graduate students for careers outside of academia; discussions led by a series of guest speakers from leading biotech industries; understanding the societal impact of basic research; participation in round-table discussions; and presentation of student research findings. Requirements: graduate standing and good academic standing in a participating department supported by the Predoctoral Training Program in Biotechnology. Same as CBE:5875, CEE:5875, CHEM:5875, MICR:5875, PHAR:5875.

BMB:7251 Introduction to Protein Structures 1 s.h.

Basics of protein structures and amino acids; module covers chapters 1-5 of Lehninger's Principles of Biochemistry. Recommendations: first-year graduate standing in biosciences or physical sciences.

BMB:7252 Enzymes, Carbohydrates, Nucleic Acids, Lipids, and Membranes 1 s.h.

Basics of enzyme kinetics and enzyme mechanisms, carbohydrates, nucleic acids, and lipids; module covers chapters 6, 7, 8, and 10 of Lehninger's Principles of Biochemistry. Recommendations: first-year graduate standing in biosciences or physical sciences.

BMB:7253 Introduction to Metabolism 1 s.h.

Introduction to metabolism including bioenergetics of metabolic reactions, biochemical signaling, and the basics of carbohydrate metabolism (glycolysis, gluconeogenesis, the pentose phosphate pathway). Module covers chapters 11,12,13, and 14 of Lehninger's Principles of Biochemistry. Recommendations: first-year graduate standing in biosciences or physical sciences.

BMB:7254 Metabolism I 1 s.h.

Glycogen metabolism, the citric acid cycle, and amino acid and fatty acid catabolism. Module covers chapters 15,16,17,and 18 of Lehninger's Principles of Biochemistry. Recommendations: first-year graduate standing in biosciences or physical sciences.

BMB:7255 Metabolism II 1 s.h.

Oxidative phosphorylation, photosynthesis, the synthesis of nitrogen-containing compounds (amino acids, nucleotides), and principles of hormonal regulation of metabolic pathways. Recommendations: first-year graduate standing in biosciences or physical sciences.

BMB:7256 Molecular Biology 1 s.h.

Chromosomal organization, DNA replication, gene expression, RNA processing, and translation; can be taken alone or as part of BMB:3130; for graduate students who wish to refresh or advance their knowledge of the central dogma of molecular biology. Recommendations: first-year graduate standing in biosciences or physical sciences.

BMB:7292 Research Biochemistry arr.

Thesis research.

BMB:8101 Biochemistry for Dental Students 3 s.h.

Biochemical concepts and application to clinical problems. Requirements: CHEM:2210 and DDS enrollment. Recommendations: CHEM:2220.