Graduate certificate: biostatistics
The Department of Biostatistics prepares students for professional and academic careers in biostatistics. Graduates find positions in pharmaceutical, health care, and research companies and institutions; in universities and government agencies; and as consultants. The department also provides training for non-biostatistics students.
Biostatistics faculty members work closely with both clinical and basic science investigators on the University of Iowa health sciences campus in the design and analysis of research projects. The department has research expertise representing a broad array of methodological areas of statistics and biostatistics, including clinical trials, computational statistics, Bayesian modeling and inference, high-dimensional data analysis, statistical genetics and genomics, bioinformatics, informatics, statistical and machine learning, spatial and spatio-temporal modeling, time series analysis, survival data analysis, longitudinal data analysis, network analysis, causal inference, comparative effectiveness studies, model selection, epidemic modeling, and syndromic surveillance. Many of these areas represent current, cutting-edge areas of disciplinary focus in a rapidly evolving field.
In addition to the M.S. and the Ph.D. degrees in biostatistics, the department offers a subprogram for the Master of Public Health (M.P.H.) degree in quantitative methods. See "M.P.H. Subprogram" below.
The Department of Biostatistics offers the quantitative methods subprogram for the Master of Public Health degree. The subprogram is designed to train public health professionals for leadership in the analysis of public health data and the design of studies for public health investigations. See the Master of Public Health in the Catalog.
Graduate Programs of Study
- Quantitative methods subprogram for the Master of Public Health degree
- Master of Science in Biostatistics
- Doctor of Philosophy in Biostatistics
Department of Biostatistics resources and activities include three centers. The Biostatistics Consulting Center provides opportunities for students to gain valuable experience working with faculty and staff in the health sciences at the University of Iowa. The Clinical Trials Statistical and Data Management Center serves the statistical design, data management, and analysis needs of a variety of multicenter clinical trials, and among those are Clinical Islet Transplantation (CIT) Consortium, Network of Excellence in Neuroscience Clinical Trials (NeuroNEXT), and the Parkingson's Progression Markers Initiative (PPMI). The Center for Public Health Statistics facilitates the collection, statistical analyses, and dissemination of health data in support of the University's research, teaching, and service missions and in partnership with the Iowa Department of Public Health.
BIOS:4110 General Biostatistics3 s.h.
Biostatistics and biostatistical computation; biostatistical aspects of health-related problems; clinical trials; statistical issues in big data problems; disease modeling; disease mapping; genetics and epidemiology; brief introduction to survival and longitudinal analyses.
BIOS:4120 Introduction to Biostatistics3 s.h.
Application of statistical techniques to biological data including descriptive statistics, probability and distributions, sampling distributions, nonparametric methods, hypothesis tests, confidence intervals, analysis of categorical data, and simple linear regression; designed for non-biostatistics majors and M.P.H. students. Requirements: college algebra or ALEKS score of 65% or higher.
BIOS:4710 Biostatistical Methods Laboratory1 s.h.
Computational aspects of one-sample and two-sample problems; analysis of frequency data, linear regression, and correlation analysis; examples using these computational methods in public health. Offered fall semesters. Prerequisites: STAT:3200 and STAT:2010.
BIOS:5120 Regression Modeling and ANOVA in the Health Sciences3 s.h.
Continuation of BIOS:4120; correlation, simple and multiple linear regression, confounding, interactions, model selection, single and multiple factor ANOVA (analysis of variance) models, contrasts, multiple comparisons, nested and block designs, and an introduction to mixed models; designed for non-biostatistics majors. Offered spring semesters and summer sessions. Prerequisites: BIOS:4120. Same as IGPI:5120, STAT:5610.
BIOS:5310 Research Data Management3 s.h.
Introduction to data management techniques and problems encountered in gathering and processing data from biomedical investigations; introduction to SAS, techniques taught in SAS; designed for non-biostatistics majors. Offered fall and spring semesters. Recommendations: prior programming experience with C, C++, Python, Java, or other. Same as IGPI:5310, STAT:5810.
BIOS:5510 Biostatistical Computing2 s.h.
Introduction to computer programming using SAS and R statistical software packages; programming language syntax, constructs, procedures, and techniques for data management, data analysis, and statistical programming commonly encountered in biostatistics; designed for first-year biostatistics majors. Offered fall semesters. Corequisites: BIOS:5710. Same as IGPI:5510.
BIOS:5710 Biostatistical Methods I4 s.h.
Probability distributions, moments, estimation, parametric and nonparametric inference for one-sample and two-sample problems, analysis of frequency data; emphasis on use of computers; designed for first-year biostatistics majors. Offered fall semesters. Requirements: two semesters of calculus. Same as IGPI:5710.
BIOS:5720 Biostatistical Methods II4 s.h.
Continuation of BIOS:5710; multi-factor ANOVA (analysis of variance), multiple comparisons, orthogonal contrasts, linear regression and correlation, regression diagnostics and remedial measures, model selection, and mixed models; designed for first-year biostatistics majors. Offered spring semesters. Prerequisites: BIOS:5710. Requirements: one semester of linear algebra. Same as IGPI:5720.
BIOS:5730 Biostatistical Methods in Categorical Data3 s.h.
Estimation of proportions, rates, risks, relative risks, and odds ratios; Mantel-Haenszel method; logistic regression (including ordinal logistic regression and multi-category nominal logistic regression); Poisson regression and negative binomial regression; methods for correlated or clustered data (conditional logistic regression, generalized estimating equations, and mixed effects models); special topics include an introduction to generalized linear models and likelihood-based inferential techniques in this framework; designed for first-year biostatistics majors. Offered spring semesters. Prerequisites: BIOS:5510 and BIOS:5710. Corequisites: BIOS:5720. Same as IGPI:5730.
BIOS:6110 Applied Categorical Data Analysis3 s.h.
Analysis of proportions, risk measures, and measures of association; Mantel-Haenszel method; logistic regression for binary responses and for matched data; logistic regression for multi-category responses; analysis of count data (Poisson regression and negative binomial regression); analysis of clustered data (generalized estimating equations and generalized linear mixed effects model); special topics include the application of propensity score methods; designed for non-biostatistics majors. Offered fall semesters. Prerequisites: BIOS:5120. Same as IGPI:6110.
BIOS:6210 Applied Survival Analysis3 s.h.
Nonparametric, parametric, and semi-parametric methods for time-to-event data; types of censoring; Kaplan-Meier estimation; Cox proportional hazards models, including methods for assessing adequacy of the proportional hazards assumption; time varying covariates; sample size calculations for comparison of two or more groups; focus on analysis of real data sets and examples using statistical software. Offered spring semesters. Prerequisites: BIOS:5120 or BIOS:5720. Same as IGPI:6210.
BIOS:6310 Introductory Longitudinal Data Analysis3 s.h.
Introduction to statistical models and estimation methods for outcome variables (normal and non-normal) clustered or measured repeatedly in time or space; focus on applications and computer software methods for ANOVA based methods, hierarchical linear models, linear mixed models, correlated regression models, generalized estimating equations, and generalized linear mixed models. Offered fall semesters. Prerequisites: BIOS:5120 or STAT:3200. Same as IGPI:6310, STAT:6550.
BIOS:6420 Survey Design and Analysis3 s.h.
Methodological issues regarding design, sampling approach, implementation, analysis, and interpretation of surveys and questionnaires in public health research. Offered spring semesters of even years. Prerequisites: EPID:4400 and BIOS:5120. Same as EPID:6420.
BIOS:6610 Statistical Methods in Clinical Trials3 s.h.
Survey of statistical methods commonly used in clinical trials; primary focus on methodologic perspective for the design, conduct, analysis, and interpretation of all phases of clinical trials; logistical and operational aspects of conducting multisite clinical trials; designed for biostatistics majors. Offered spring semesters. Prerequisites: BIOS:5720. Requirements: familiarity with SAS and R programming. Same as IGPI:6610.
BIOS:6650 Causal Inference3 s.h.
Concepts of causal inference, counterfactuals, confounding, causal graphs, internal/external validity, heterogeneity of treatment effect; methods covered include propensity score matching (optimal pair, multiple control and full matching; near-exact, fine-balance, and risk set matching) and stratification; covariate balance checks; sensitivity analysis; inverse probability of treatment weighted estimation; doubly robust estimators; mediation analysis; marginal structural models. Offered fall semesters of odd years. Prerequisites: BIOS:5720 and BIOS:5730 and ((STAT:4100 and STAT:4101) or (STAT:5100 and STAT:5101)). Same as IGPI:6650.
BIOS:6720 Statistical Machine Learning for Biomedical and Public Health Data3 s.h.
Statistical machine learning techniques for analysis of biomedical and public health data; methodology and application of unsupervised learning, supervised learning for regression and classification, ensemble learning, model assessment, feature selection, and high-dimensional inference. Prerequisites: BIOS:5510 and BIOS:5720 and (STAT:4100 and STAT:4101) or (STAT:5100 and STAT:5101). Requirements: BIOS:5510 with topic of programming with R.
BIOS:6810 Bayesian Methods and Design3 s.h.
Theory and application of Bayesian methods in biomedical research; foundations of Bayesian statistics including decision theory, study design, model development, inference and implementation of computational algorithms; designed for biostatistics majors. Offered spring semesters of odd years. Prerequisites: BIOS:5510 and BIOS:5720 and BIOS:5730 and STAT:4100 and STAT:4101.
BIOS:7110 Theory of Biostatistics I4 s.h.
Intermediate-level treatment of the theoretical foundation of mathematical statistics including conditional distributions, models, prediction, sufficiency, exponential families, methods of estimation and performance of estimators, uniform minimum variance unbiasedness, information inequalities, likelihood theory, confidence intervals, asymptotic theory and its applications; designed for biostatistics majors. Offered fall semesters. Prerequisites: (BIOS:5720 and STAT:5100 and STAT:5101) or (STAT:4100 and STAT:4101).
BIOS:7120 Theory of Biostatistics II4 s.h.
Asymptotic likelihood theory for estimation and hypothesis testing with and without nuisance parameters; generalized linear models; numerical optimization; model and data deficiencies, (e.g., misspecified models, missing data, robust variance estimation); alternative likelihoods (e.g., profile, conditional, marginal, pseudo, partial, quasi likelihoods); EM algorithm; topics may include bootstrap, rank-based methods, propensity scores, double-robust estimators, generalized linear mixed models and numerical quadrature methods; designed for biostatistics majors. Offered spring semesters. Prerequisites: BIOS:7110.
BIOS:7210 Survival Data Analysis3 s.h.
Types of censoring and truncation; survival function estimation; parametric inference using exponential, Weibull, and accelerated failure time models; nonparametric tests; sample size calculation; Cox regression with stratification and time-dependent covariates; regression diagnostics; competing risks; topics may include analysis of correlated survival data and/or recurrent events; designed for biostatistics and statistics majors. Offered fall semesters. Prerequisites: BIOS:5720 and ((STAT:4100 and STAT:4101) or (STAT:5100 and STAT:5101)). Same as IGPI:7210, STAT:7570.
BIOS:7230 Advanced Clinical Trials3 s.h.
Modules that address advanced topics and issues encountered when conducting a clinical trial; discussions of recent publications and FDA guidance documents dealing with current topics in clinical trials. Prerequisites: (STAT:4101 or STAT:5101) and BIOS:6610. Requirements: familiarity with SAS and R programming.
BIOS:7240 High-Dimensional Data Analysis3 s.h.
Analysis of high-dimensional data with emphasis on use of penalized regression models such as lasso, elastic net, minimax concave penalty (MCP), smoothly clipped absolute deviation (SCAD), and group lasso; large-scale hypothesis testing and false discovery rate estimation; inference for penalized likelihoods. Prerequisites: (STAT:4100 and STAT:4101) or (STAT:5100 and STAT:5101) and BIOS:5510 and BIOS:5720. Requirements: BIOS:5510 with section subtitle of programming with R.
BIOS:7270 Scholarly Integrity in Biostatistics1 s.h.
Responsible conduct of research training; emphasis on issues of particular relevance to biostatisticians including authorship, communication, student/mentor relationships, plagiarism, fabrication and falsification of data, bias, Type I/II errors, reproducible research, data confidentiality and security, conflicts of interest, and human/animal subjects. Requirements: graduate standing in biostatistics.
BIOS:7310 Longitudinal Data Analysis3 s.h.
Statistical models and estimation methods for outcome variables (normal and non-normal) clustered or measured repeatedly in time or space; includes ANOVA based methods, hierarchical linear models, linear mixed models, error structures, generalized estimating equations, and generalized linear mixed models; may include Bayesian approaches; designed for biostatistics and statistics majors. Offered spring semesters of odd years. Prerequisites: (BIOS:5720 and STAT:4100 and STAT:4101) or (STAT:5100 and STAT:5101). Same as IGPI:7310.
BIOS:7330 Advanced Biostatistical Computing3 s.h.
Advanced topics in biostatistical computing and large or complicated data/models; matrix decomposition, optimization, Bayesian computing, parallel programming, working with campus high performance computing (HPC) resources; topics are explored in R, including package development and efficient R code. Prerequisites: MATH:2700 and BIOS:5510 and STAT:4101. Requirements: BIOS:5510 with section subtitle of programming with R.
BIOS:7410 Analysis of Categorical Data3 s.h.
Models for discrete data, distribution theory, maximum likelihood and weighted least squares estimation for categorical data, tests of fit, models selection. Offered spring semesters. Prerequisites: (BIOS:5720 or STAT:5200) and (STAT:5101 or STAT:4101). Same as STAT:7510.
BIOS:7500 Preceptorship in Biostatisticsarr.
Work experience using knowledge and skill acquired in classroom; arranged in conjunction with ongoing departmental or collegiate activities or with governmental agencies or private industry; preparation of prospectus and presentation of research results in a department seminar.
BIOS:7600 Advanced Biostatistics Seminar0-3 s.h.
Current topics; supervised experience in reading and interpreting biostatistical literature. Same as IGPI:7600.
BIOS:7604 Scholarly Integrity in Biostatistics for Postdocs0 s.h.
Responsible conduct of research training; emphasis on issues of particular relevance to biostatisticians and statisticians including authorship, communication, student/mentor relationships, plagiarism, fabrication and falsification of data, bias, Type I/II errors, reproducible research, data confidentiality and security, conflicts of interest, human/animal subjects. Requirements: postdoctoral research scholar/fellow standing in biostatistics or statistics.
BIOS:7700 Problems/Special Topics in Biostatisticsarr.
Didactic material in biostatistics; may include tutorials, seminars, faculty-directed independent work (e.g. literature search, project, short research project).
BIOS:7800 Independent Study in Biostatisticsarr.
In-depth pursuit of an area of special interest in biostatistics requiring substantial creativity and independence.
BIOS:7850 Research in Biostatisticsarr.
Research that may lead to a dissertation.